Originally from Africa, Mari McCabe grew up an orphan after her parents were killed by local greed, corruption and wanton violence. But Mari refuses to succumb to the terrors surrounding her. Inheriting her family's Anansi Totem, Mari can access the powers of animals - anything from the super-strength of a gorilla to the speed of a cheetah. As Vixen, she fights valiantly to protect the world from threats like those that claimed her family.

The world is under attack by an alien armada led by the powerful Apokoliptian, Darkseid. A group of superheroes consisting of Superman, Batman, Wonder Woman, The Flash, Green Lantern, Cyborg, and Shazam must set aside their differences and gather together to defend Earth.