After a disease kills 98% of America's children, the surviving 2% develop superpowers and are placed in internment camps. A 16-year-old girl escapes her camp and joins a group of other teens on the run from the government.

Billy "The Great" Hope, the reigning junior middleweight boxing champion, has an impressive career, a loving wife and daughter, and a lavish lifestyle. However, when tragedy strikes, Billy hits rock bottom, losing his family, his house and his manager. He soon finds an unlikely savior in Tick Willis, a former fighter who trains the city's toughest amateur boxers. With his future on the line, Hope fights to reclaim the trust of those he loves the most.